herbal Medicines

Natural products remain one of the largest source of new drugs; for millions of years, we have relied on natural products, even in their crudest form, to treat a variety of ailments, from heart disease to skin warts. Chinese herbal medicines, particularly for the treatment of skin disorders have been in use for a long time. The inventions shown below are based on converting anecdotal use of Chinese medicine into a scientific portfolio, to make them better acceptable to regulatory agencies such as FDA that has recently started a new Division of Complimentary and Alternate Medicines to approve these drugs.


US 6,555,118 | Pharmaceutical Preparation for The Treatment of Topical Wounds and Ulcers.

Topical ointment, containing extract of Huangqin, Huanglian, Huangbai, Opuntia, Dilong, and ß-sitosterol (from Soybean extract), in a vegetable oil-wax base, without any preservatives and more distinctly without opium that is common in Chinese products for topical application. The mechanism of action is stimulation of stem cells from ß-sitostero, while other components provide antiseptic and other healing action without scarring. Proven effective for treating second and third degree burns, stasis ulcers, trophic lesions, such as decubitus ulcers, diabetic ulcers, surgical wounds, severe cuts, diaper rash, cracked nipples and abrasions. PDF 


US 6,495,174 | Herbal Composition for The Treatment of Alopecia.

Pharmaceutical compositions for the topical treatment of alopecia containing alcoholic extracts of Rhizoma zingiberis recens, Rhizoma pinelliae, Flos carthami, Radix rehmanniae, Radix angelicae sinesis, Radix paenoiae rubra, Cacumen biotae, Semen sesami nigrum, Radix polygoni multiflori, Fructus mori, Capsicum, Cantharidin, and Oleum ricini. Mechanism of action involves  ß-cell stimulation, local irritation and dihdyrotestostrone level management. PDF


US 6,447,820 | Pharmaceutical Composition for The Prevention and Treatment of Scar Tissue.

Compositions for treatment of existing and prevention of new skin scars containing alcoholic extracts of Cortex Phellodendri and Opuntia ficus indica. Effective in removing pregnancy stretch marks, surgical scars even chronic ones. PDF


US 6,419,963 | Composition and Method for The Treatment of Diaper Rash Using Natural Product.

Already marketed for the treatment of diaper rash in the US containing beeswax, olive oil, ß-sitosterol and the herb Coptis chinesis Franch for safe and quick treatment for infant and adult diaper rash. Free of any water-based component, the ointment also acts as humectant. PDF


US 6,365,198 | Pharmaceutical Preparation for The Treatment of Gastrointestinal Ulcers and Hemorrhoids.

Treatment of gastrointestinal ulcers and hemorrhoids for oral or rectal administration of extract of Huangqin, Huanglian, Huangbo, Opuntia and Pheretima dissolved in vegetable oil. PDF


US 6,312,735 | Method for Instantaneous Removal of Warts and Moles.

Cauterization of wart with slaked lime followed by scratching the surface of wart with stem of betel leaf. PDF


US 10/604,424 | Pharmaceutical Composition for The Treatment of Itch.

Topical preparations for the treatment of topical itch containing Opuntia, Propolis, Stearic Acid, Beeswax, Vegetable Oil and ß-sitosterol. Itch includes scratch reaction itch, anal itch, or irritant itch due to plants (e.g., poison ivy), insect bite, sunburn, chemical itch, eczema, pruritis dermatitis, diabetic skin itch, aging skin itch, foot-itch, chickenpox, jock itch, hives, itch of healing burns and wounds, dry winter skin itch, and stress-related scalp itch, etc. PDF


US 10/250197 | Compositions and Methods for Reducing or Controlling Blood Cholesterol, Lipoproteins, Triglycerides, And Sugar and Preventing or Treating Cardiovascular Diseases.

Oral product containing psyllium husk, ß-sitosterol, guggul tree extract, guar gum and chromium  reduce or control blood cholesterol, triglycerides, low density lipoproteins, blood sugar or increasing or controlling high density lipoproteins and further reduce arterial plaque build-up, atherosclerosis associated with cardiovascular, cerebrovascular, peripheral vascular, or intestinal vascular disorders. PDF


US 10/077,289 | Pharmaceutical composition for the treatment of alopecia.

Pharmaceutical compositions containing phystosterols and/or blood flow stimulants to promote hair growth through stimulation of follicular cells, bulb cells and stem cells in the scalp. PDF


US 09/957,773 | Composition and Method for The Treatment of Hypercholesterolemia and Hyperlipidemia in Mammals.

Oral compositions containing Zizyphus jujube to treat atherosclerosis, post-angioplasty restenosis, coronary artery disease, angina, small artery disease and other diseases caused by or are the result of hypercholesterolemia. PDF


US 09/949,445 | Method and Composition for Reducing Sebum Secretion in Mammals.

Compositions to reduce sebum production on the skin using a surfactant, a chylomicron disrupter, a skin penetration enhancer, and an anti-androgenic compound. PDF

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Ethical medicines

US 6,338,862 | Composition and Method of Use in Treating Sexual Dysfunction Using C-GMP-Specific Phosphodiesterase Type 5 Inhibitors.

A combination of sildenafil citrate (Viagra®) or any inhibitors of cyclic guanosine monophosphate (cGMP) phosphodiesterases type 5 (cGMP-PDE5) is enhanced by combining with L-arginine, ginseng, vitamin B6, vitamin B12, and folic acid. A lower dose of Viagra® can be used for the same response reducing side effects. PDF


US 6,251,421 | Pharmaceutical Composition Containing Psyllium Fiber and a Lipase Inhibitor

Pharmaceutical compositions containing an inhibitor of gastrointestinal lipase, and at least one compound selected from the group consisting of psyllium husk, its seeds and leaves thereof. Methods are provided for preventing and treating anal leakage of oil in a patient to whom a composition containing an inhibitor of gastrointestinal lipase is orally administered. A pharmaceutical composition in oral dosage form for humans, said composition comprising an inhibitor of gastrointestinal lipase, said gastrointestinal lipase is present in an amount of from about 10 mg to about 500 mg, and a compound comprising psyllium husk, seeds or leaves thereof, said compound is present in an amount of from about 500 mg to about 20 g, wherein said composition contains 10 to 50 parts by weight of the compound per 1 part by weight of the inhibitor of gastrointestinal lipase. PDF


US 6,235,796 | Use of Fluorocarbons for The Prevention of Surgical Adhesions.

Method for the prevention and inhibition of adhesion between tissues comprising the use of fluorocarbons are disclosed. The method provides for the introduction of a fluorocarbon into the surgical site of a mammalian body, such as a human, to minimize friction and enhance the mobility of the surrounding tissues and organs. PDF


US 6,235,314 | Analgesic, Anti-Inflammatory and Skeletal Muscle Relaxant Compositions.

 Disclosed is a local skeletal muscle relaxant and a non-steroidal anti-inflammatory drug in a topical composition for topical application to a patient for relief of pain. More particularly and in its preferred form, the invention involves a combination of diazepam and diclofenac in a composition for topical application to the skin of a patient as a colorless transparent gel. A composition for topical application to a body surface, comprising: 0.5% to 2.5% carbomer, 50% to 65% H2 O, 1.5% to 3.5% paraffin, 1.5% to 3.0% emollient, 1.0% to 3.0% emulsifier, 0.5% to 2.0% diethylamine, 0.5% to 3.0% pharmaceutically acceptable neutralizing base, 20% to 30% alcohol, 1.5% to 5.0% propylene glycol, 0.1% to 5.0% diazepam, 0.1% to 5.0% nonsteroidal anti-inflammatory drug in a homogenized mixture. PDF


US 4,530,936 | Composition and Method for Inhibiting the Absorption of Nutritional Elements from The Upper Intestinal Tract.

A method of inhibiting the absorption of nutritional elements, principally food, from the gastrointesinal tract is disclosed which comprises ingesting perfluorodecalin in an amount sufficient to form a nutritional element-impermeable film thereof on at least a substantial part of the inner wall of the upper intestine and maintaining the film for a time long enough to inhibit the absorption from the gastrointestinal tract of a significant proportion of the ingested nutritional elements. PDF


US 11/306155 | Alleviation of Pain in Osteoarthritis by Means of Intra-Articular Implantation of Perfluorodecalin.

A method of alleviating pain in osteochondral lesions by means of intra-articular implantation of perfluorodecalin, a fully fluorinated fluorocarbon. The main objective of the invention is to introduce the new medical use of perfluorodecalin for the alleviation of pain when injected into joints wherein perfluorodecalin provides a lubrication and viscoelastic function that allows smooth movement of joints without appreciable pain. PDF

US 11/053,400 | Formula, a system and a method for treating urushiol induced contact dermatitis.


A formula, a system and a method is provided for treating urushiol induced contact dermatitis, chemical irritants and/or microbiological irritants on an affected area of skin of a user. The formula and/or the system have a cleansing agent, one or more surfactants and/or one or more abrasive agents for treating the urushiol induced contact dermatitis, the chemical irritants and/or the microbiological irritants. PDF

US 09/681254 | Combination of multiple non-steroidal anti-inflammatory drugs and muscle relaxants for local treatment of musculoskeletal pain. 

A pharmaceutical composition for use in the treatment of pain and inflammation and the treatment of muscle spasms and associated pain, soreness and tightness of muscles by topical administration of a combination of an analgesic and anti-inflammatory effective amount of at least one drug chosen from each of the groups of NSAIDs consisting of propionic acid derivatives, acetic acid derivatives, fenamic acid derivatives, biphenyl carbolic acid derivatives, oxicam derivatives; and an amount effective in the treatment of muscle spasms, and associated symptoms, of a muscle relaxant selected from the group consisting of cyclobenzaprine, chlorzoxanzone, methocarbamol, dantrolene and the pharmaceutically acceptable salts thereof.  PDF


US 09/681127 | Vaginal Administration of Apomorphine to treat sexual dysfunction in females.

Vaginal administration of a dopaminergic agent, apomorphine, instantly treats sexual dysfunction in frigid women wherein apomorphine is delivered through a vaginal suppository resulting in sufficient increase in intra-clitoral blood flow and vaginal wall blood flow to stimulate women but less than the amount that induces substantial nausea, the typical side effect of using apomorphine given systemically. PDF


US 09/681117 | Use of lizard oil in treating sexual impotency and frigidity.

A method of using animal fats derived from Uromastix hardwickii containing high concentration of a specific natural long-chain acid, erucic acid, to treat male erectile dysfunction. When applied to penile area, the raw fat induces erection to treat  impotence in men. PDF


US 09/681110 | Use of erucic acid in enhancing blood flow to tissues.

Compositions for the application of erucic acid as an adjuvant to enhance blood flow to tissue. This GRAS compound enhances blood flow to peripheral tissues upon local application; applications tested in treating male erectile dysfunction and female frigidity are discovered both alone and in combination with sildenafil and apomorphine. Significant role in arthritis, diabetes afflicted patient treatment and enhancing effects of other drugs applied locally. A method for enhancing blood flow to tissues by applying erucic acid. PDF.

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Reading comprehension

Books are historically printed with text aligned horizontally and whereas we get used to reading even when we tilt head to right or left when our eyes are misaligned, such is not the case with those suffering from dyslexia or ADHD; text printed at an angle resolves this problem.

US 15/188636 | Visual Axis Optimization for Enhanced Readability and Comprehension.

Angled printing allows those with dyslexia and ADHD improve their reading and comprehension abilities.

Angled printing allows those with dyslexia and ADHD improve their reading and comprehension abilities.

A method for improving readability and comprehension of text and images by those in need of improving readability and comprehension of text and images comprising printing the text and images at an angle to reduce misalignment of a horizontal axis of the eyes and a horizontal axis of a printed text and image. PDF

15/383,971 | Angled Printed Book.

A method for improving readability and comprehension of printed text or image by printing at an angle as a mirror image on the left and right page of a bound book is disclosed. A book comprising: a plurality of bound leaves having a left page and a right page; a text or an image printed at an angle as mirror images on the left and the right pages in angular orientation. PDF.

14/308462 | Visual Axis Optimization for Enhanced Readability and Comprehension.

A method of improving readability and comprehension of text and images comprising printing or displaying the text and images at an angle to align with the horizontal axis of the eyes of the reader. PDF

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Drug Delivery

 Many drugs are not administered orally because they are decomposed by the gastrointestinal fluids or during passage through liver. One of the most reliable route of administration is through suppositories; the invention below describes a suppository base using erucic acid that helps improve local circulation and therefore, the absorption of drug contained in the suppository. A blank suppository can be used to stimulate female sex organs as well.


US 6,462,083 | Suppository Base.

A suppository base composition of erucic acid and beeswax with improved chemical stability, moldability, and shelf-life. The inventive suppository base also stimulates localized blood flow to the administration site. A suppository base composition comprising erucic acid present in an amount of about 90 to about 99 percent by weight and beeswax present in in an amount of about 1 to about 10 percent by weight. PDF

US 4,639,368 | Chewing gum containing a medicament and taste maskers.

 Drugs administered through buccal cavity avoid both impediments but the bitter taste of many drugs makes this a less desirable route of administration. In the invention described below, a chewing gum base is used wherein carbon dioxide is produced upon chewing that helps anesthetize taste buds to allow bitter drug taken through buccal cavity, such as various amines used for weight loss management.


A chewing gum composition adapted to supply a medicament to the oral cavity for local application thereto or for buccal absorption of said medicament which comprises a chewing gum base, an orally administrable medicament, a taste masking generator of carbon dioxide and optionally a taste bud desensitizing composition. A chewing gum composition adapted to supply a medicament to the oral cavity comprising, a chewing gum base, an orally administrable medicament capable of being absorbed through the buccal cavity, said medicament consisting essentially of phenylpropanolamine, and a carbon dioxide generator. PDF

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Clinical Testing

Drug actions are often proportional to the quantity of drug at the site of action; what drives molecules within the body is its thermodynamic activity, not the observed concentration. Based on this observation, methods for testing drug activity are described that remove the need to expose humans to testing new drugs for their activity evaluation. Protein drugs can change their structure and their activity and toxicity because of changes in their structure; a thermodynamic stress applied to molecules causing a shift in structure is used to compare molecular structures.


US 14/160837 | Thermodynamic Equivalence Surrogate Test (TEST) For Bioequivalence.

 A method for establishing bioequivalence of drug products by comparing the thermodynamic potential of the release of a drug substance from drug products according to a set of statistically differentiated dissolution profiles of an active drug substance contained in the drug product. PDF

US 13/961571 | Methods for Comparing a Structure of a First Biomolecule and a Second Biomolecule.

 Methods to assess structural similarity of a first biomolecule and a second biomolecule by detecting one or more responses of the first and second biomolecule to thermodynamic stress conditions induced by osmotic and dielectric changes including, detecting a shift in fluorescence emission and/or a change in the intensity of the emission. PDF

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