New drugs in the next millenium
For centuries scientists have searched for new drugs in and around their surroundings believing firmly that Nature would not have allowed a disease to sprout without its cure being around somewhere. They have come up with dramatic successes, from penicillins and aspirin to sildenafil (Viagra®). The last quarter of this century made available to scientists, newer tools that allowed them to look deeper, inside the body for clues to new drugs. Techniques that require extensive use of super-computers and automated robotic analysis allowed scientists to begin mapping human genes to look for connections to diseases and henceforth, design drugs to treat them. Today, we stand at a junction of explosive drug discoveries, the likes of which could not even have been conceived only 10 years ago. The double helix of DNA in our body holds the key to all what we are—including our disposition to disease. The genetic material produces in our body a large number of small proteins, the presence of which prevents disease or cause disease if this happens to be an abnormal protein. Knowing which genes produce these abnormal proteins or when defective gene are present, which protein are not formed in the body or perhaps formed excessively, holds the key to new drug discovery in the next millenium. Not only would we be able to tell which diseases we are predisposed to, we would be able to have custom designed drugs synthesized based on our analysis of proteins in the blood. It will be analogous to getting a CBC done today and then the doctor ordering a cocktail of small proteins to cure all of our illnesses, aging, impotence and even our sagging memory and skin to possibly intelligence and morality. The excitement in the eyes of the scientists today looking onto the printouts of coding of human genes is infectious. Billions of dollars are being poured into this new line of drugs hoping that one day we would have a panacea for today’s pressing illnesses like cancer and heart disease. Once conquered, we can look forward a newer breed of drugs dubbed as "lifestyle" drugs to improve our quality of life—longevity, youth, intelligence, memory and ultimately, happiness.